Interventional Psychiatry · Integration

Ketamine works fast. Integration makes it last.

We pair every ketamine and Spravato dose with real therapy, timed to when the brain is most ready to change.

What one cycle looks like
The dose
IV ketamine or Spravato, under supervision
Day 1
The window opens
The brain is briefly more changeable
Days 1 – 3
Integration
Therapy that has a chance to stick
Days 2 – 3

Repeated across a short series, then tapered as gains hold.

Why it works

Why the dose alone is not enough

Ketamine and Spravato lift depression in hours, not weeks. But for many people that lift fades within about a week unless something holds it in place. On its own, ketamine can become a series of resets that never quite add up to recovery.

The same biology that lifts mood also makes the brain briefly more changeable. Therapy timed to that opening is what turns a fast result into a lasting one.

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The neuroplasticity window

For about 24 to 72 hours after a dose, the brain forms new connections more easily. Integration takes advantage of that plasticity to encourage new learning and strengthen new connectivity while the window is open, so the change has a chance to hold.
Why the dose alone is not enough
The evidence, plainly

What the science shows, and what it does not yet

We would rather show you the honest split than sell certainty that is not there.

Well established

Replicated in trials and clinical use.

Fast relief for depression that has not responded to other medications.
Spravato FDA approved since 2019, and approved on its own in 2025.
A real, measurable window of brain plasticity after each dose.

Still emerging

Strong rationale, encouraging early data.

How much adding therapy beats the dose alone. Few trials so far, results mixed.
Exactly how long it extends durability. Being studied now.
The best therapy and timing to use.

Where we land: the medical effect is proven, and using the window it opens is well reasoned and backed by early results. The size of that added benefit is still being studied. Anyone promising certainty is ahead of the evidence, so we build on therapies that already have their own track record.

The model

What integration includes

A real sequence, not a vibe. Each dose sits inside a structure built to make it count.

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Each dose works best when it's part of a plan, not a one-off. That's the whole idea here. We start by making sure this is the right fit for you and getting clear on what you're hoping for.

The dosing itself happens somewhere calm, with a clinician right there the whole time. Then comes the part most clinics skip: in the days right after, while your brain is most open to change, we put in the real therapy work—proven approaches like CBT, EMDR, and DBT—so the shifts you feel have a chance to actually stick.

Along the way we keep track of how you're doing and adjust early if things stall, and as you find your footing, we ease back on the dosing and lean into your own skills, with a plan in place to keep you steady.

The dose opens a window. Everything we build around it is what helps the change last.

1

Preparation

We confirm the fit, set clear goals, and walk you through what to expect.

2

Dosing

Given in a calm, monitored setting with a clinician present throughout.

3

Integration

The part most clinics skip. In the days after each dose, while the brain is most plastic, we use proven therapy, including CBT, behavioral activation, EMDR, and DBT, to encourage new learning and strengthen new connections, so what changes has a chance to stay changed.

4

Measurement

We track symptoms with standard measures and adjust early if they stall.

5

Maintenance

We taper dosing as gains hold and shift the weight onto your skills, with a relapse plan.

Plain about it

What this is not

Not a guided journey

A medication with a mechanism, used for a clinical reason. No mysticism.

Not a drive through infusion

The therapy is the point, not an add on bolted to a procedure.

Not an oversold cure

We measure whether it works and tell you the truth either way.

Who this tends to help
Is it for you

Who this tends to help

Depression that has not responded to two or more antidepressants.
Past relief from ketamine or Spravato that did not hold once dosing stopped.
Depression alongside trauma, anxiety, or OCD, where targeted therapy has clear work to do.
A point where waiting weeks for a medication to work is not an option.

Whether it is the right step is a clinical decision we make with you, after an evaluation. Some people are better served by another path, and we will say so.

Straight answers

Questions people actually ask

Is this just a ketamine clinic with extra steps?

No. A standalone clinic gives you the dose and the door. We build evidence based therapy around each dose and track whether it is working.

Does insurance cover it?

Spravato is covered by most commercial plans and Medicaid when criteria are met, and we stay in network across Ohio and Indiana. We confirm your specific benefits before anything begins.

What therapy do you use?

Established methods matched to your goals: CBT, behavioral activation, exposure work for OCD, EMDR for trauma, and DBT skills. Integration delivers them when they are most likely to stick.

What is the honest downside?

The medication has side effects, including that detachment, brief blood pressure changes, and nausea for some. And while the case for integration is strong, the exact size of its added benefit is still being studied.

Find out if this is the right step

An evaluation tells us whether ketamine or Spravato with integration fits your situation.